AI-Driven Efficient De Novo design of GLP-1RAs with Extended Half-Life and Enhanced Efficacy
Ting Wei, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Taiying Cui, Cheng Liu, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Zhangsheng Yu, Haifeng Chen
This paper designs 10,000 de novo GLP-1RAs using AI, with 60 passing stability, efficacy, and diversity criteria, and two showing extended half-lives and superior efficacy in vivo.
bioRxiv · Mar 26, 2025 · PreprintBioengineering