Xiaokun Hong

DynaRNA generates RNA conformation ensembles using a diffusion model with EGNN, outperforming MD simulations in accuracy and efficiency.

This paper designs 10,000 de novo GLP-1RAs using AI, with 60 passing stability, efficacy, and diversity criteria, and two showing extended half-lives and superior efficacy in vivo.

This paper introduces IDPFold, a diffusion model that generates conformational ensembles for intrinsically disordered proteins directly from sequences, without requiring MSA or experimental data.