A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation
Takahiro Kimura, Takuya Katayama, Shion Ishikawa, Shrutarshi Mitra, Yuuhei Yamano, Kazumitsu Onizuka, Fumi Nagatsugi, Shilpi Laha, Athi N. Naganathan, Yuji Itoh, Satoshi Takahashi
This study shows a specific SARS-CoV-2 genomic RNA region forms compact granular structures autonomously without the N protein, and the N protein melts these structures, suggesting it acts as an RNA chaperone.
bioRxiv · May 15, 2026 · PreprintBiophysics