Author

Shilpi Laha

Indian Institute of Technology Madras

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1 Organism:yeast· 1

Frequent Co-Authors

Athi N. NaganathaniD· 2 shared Satoshi TakahashiiD· 2 shared Yuji ItohiD· 2 shared David De SanchoiD· 1 shared Fumi NagatsugiiD· 1 shared Harshavardhan Madhan· 1 shared Kazumitsu OnizukaiD· 1 shared Shion IshikawaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiophysics

Athi N. NaganathanORCID

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2 papers

Recent·Most cited

Switching Functional DNA-Binding Modes by Tuning Protein Order-Disorder Equilibria

Shilpi Laha, Harshavardhan Madhan, Yuji Itoh, David De Sancho, Satoshi Takahashi, Athi N. Naganathan

This study shows how phosphorylation tuning affects Nhp6A's conformational equilibria and DNA binding modes, revealing a conserved mechanism for chromatin regulation.

bioRxiv · Aug 18, 2026 · PreprintBiophysics

A Structural Domain in the genomic RNA of SARS-CoV-2 Folds into a Compact Granular Structure without the N protein: A Single-Molecule Fluorescence Spectroscopic Investigation

Takahiro Kimura, Takuya Katayama, Shion Ishikawa, Shrutarshi Mitra, Yuuhei Yamano, Kazumitsu Onizuka, Fumi Nagatsugi, Shilpi Laha, Athi N. Naganathan, Yuji Itoh, Satoshi Takahashi

This study shows a specific SARS-CoV-2 genomic RNA region forms compact granular structures autonomously without the N protein, and the N protein melts these structures, suggesting it acts as an RNA chaperone.

bioRxiv · May 15, 2026 · PreprintBiophysics