In Vivo mRNA Hacking with Staple Oligomers Prevents Myocardial Hypertrophy
Yousuke Katsuda, Takuto Kamura, Tomoki Kida, Takeru Saeki, Yua Itsuki, Yuri Kato, Taishi Nakamura, Motohiro Nishida, Yusuke Kitamura, Toshihiro Ihara, Masaki Hagihara, Shin‐ichi Sato
This paper introduces a method to suppress target protein translation by inducing RNA G-quadruplex structures using Staple oligomers, demonstrating efficacy in preventing cardiac hypertrophy in mice.
bioRxiv · Apr 18, 2023 · PreprintMolecular Biology