Molecular BiologybioRxivPreprint
In Vivo mRNA Hacking with Staple Oligomers Prevents Myocardial Hypertrophy
Yousuke Katsuda, Takuto Kamura, Tomoki Kida…·Shin‐ichi Sato
This paper introduces a method to suppress target protein translation by inducing RNA G-quadruplex structures using Staple oligomers, demonstrating efficacy in preventing cardiac hypertrophy in mice.
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