Excess Met1-ubiquitination leads to solid aggregate formation
Stephanie Kaypee, Minori Miyasaka, Takuto NAKAJIMA, Hiromi Nishimura, Jun-Ichi Sakamaki, Masaaki Komatsu, Fumiyo Ikeda
This study shows that reduced HOIL-1 activity increases Met1-ubiquitin chains, leading to solid protein aggregates and impaired autophagy in neurodegenerative diseases.
bioRxiv · Jan 20, 2026 · PreprintCell Biology