The long non-coding RNA FAM30A regulates the Musashi2-RUNX1 axis and is required for LSC function in AML cells
Jaime Calvo Sánchez, Mary T. Scott, Athina Varnava, Tala Alakhras, Alice Wedler, Danny Misiak, Nadine Bley, Christian H. Ihling, Andrea Sinz, Karen Keeshan, Stefan Hüttelmaier, David L.P. Vetrie, Marcel Köhn
This study identifies FAM30A as a regulator of LSC function in AML by interacting with MSI2 and RUNX1, enhancing stemness and chemoresistance.
bioRxiv · Oct 13, 2024 · PreprintCancer Biology