Disconnect Between Succinate, Succinyl-CoA, and Histone Succinylation in Cells and Gastrointestinal Stromal Tumors with Succinate Dehydrogenase Deficiency
Adam G. Chatoff, Trisha Gullapudi, Sun Venkat, Talha Chaudhry, Mariola M. Marcinkiewicz, Jane Koshy, Kiara Hackey, Kathy Cai, Sarah Graff, Stephanie Stransky, Simone Sidoli, Lori A. Rink, Nathaniel W. Snyder
This study investigates the metabolic and epigenetic changes in SDH-deficient cells and tumors, finding increased succinyl-CoA but no corresponding increase in histone succinylation or significant effects from desuccinylase inhibition.
bioRxiv · Oct 7, 2026 · PreprintCancer Biology