Sarah Graff

This study investigates the metabolic and epigenetic changes in SDH-deficient cells and tumors, finding increased succinyl-CoA but no corresponding increase in histone succinylation or significant effects from desuccinylase inhibition.

This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

This study identifies SLC25A1-mediated citrate transport as a mechanism protecting pancreatic cancer cells from ferroptosis under nutrient stress, with therapeutic implications for PDAC.

The paper uses CRISPR-Cas9 screens to identify genes affecting stem cell fitness versus pluripotency identity, finding distinct and overlapping roles for chromatin and metabolic regulators.

This study shows that transcription restart after DNA replication promotes chromatin reestablishment but is also linked to genotoxic stress.

This study identifies TMEM106B as an insoluble protein increased in MS plaques and shows its deletion causes axonal damage and lipid accumulation in demyelination models.