Stephanie Stransky

This study shows KAT6 and KAT7 maintain mitotic chromatin acetylation and composition, supporting postmitotic transcriptional memory and developmental competence in stem cells.

This study investigates the metabolic and epigenetic changes in SDH-deficient cells and tumors, finding increased succinyl-CoA but no corresponding increase in histone succinylation or significant effects from desuccinylase inhibition.

This study shows that histone propionylation, influenced by nutrient availability, regulates T cell fate and antitumor immunity.

This study identifies histone succinylation as an inhibitor of JmjC demethylases, leading to stabilized repressive chromatin states and reduced transcription.

The paper shows that inhibiting the CoREST complex with corin alters RNA splicing, increases neoantigen expression, and enhances tumor immunity in melanoma.

The paper shows PRMT5 promotes chromatin escape of mRNAs by methylating SNRPB, affecting splicing and nuclear export.

This paper identifies EZH1-dependent H3K27me1 as an adaptive chromatin barrier limiting DNMT inhibitor response in colorectal cancer and shows that dual EZH1/2 inhibition synergizes with DNMTi to enhance therapeutic efficacy.

The paper shows that H3K36M oncohistone inhibits NSD2, leading to SETD2-dependent antiviral immune response and tumor clearance in KRAS-driven lung cancer.

This study shows that CARM1 loss in GSCs disrupts developmental programming, shifts lineage towards radial glia, and creates a dependency on NGFR/NTRK signaling, making them vulnerable to NTRK inhibitors.

This study identifies histones as exosome membrane proteins regulated by cell stress, showing they are secreted via the exosome pathway and lack nuclear post-translational modifications.

This study shows PROSER1 regulates DNA demethylation through dual mechanisms, balancing gene expression and preventing developmental malformations.

The paper identifies EXOSC4's interaction with a specific histone modification pair and shows its role in regulating non-coding transcription.

This study shows that LSD1's non-catalytic function regulates DNA methylation in mouse ESCs by controlling UHRF1 and DNMT1 stability through USP7 interaction.

The paper identifies an aging-associated chromatin state in mice and shows that liver regeneration reverses it.

A single enzyme, TGM2, bidirectionally controls H3 monoaminylation dynamics, which, in turn, facilitate neural rhythmicity.

The paper identifies endogenous interactors of Neurexin's intracellular domain in C. elegans using proximity ligation and mass spectrometry, revealing novel proteins involved in presynaptic function.