Single-cell transcriptomics reveal diverging pathobiology and opportunities for precision targeting in scleroderma-associated versus idiopathic pulmonary arterial hypertension
Tijana Tuhy, Julie C. Coursen, Tammy Graves, Michael Patatanian, Christopher Cherry, Shannon E. Niedermeyer, Sarah L. Khan, Darin T. Rosen, Michael P. Croglio, Mohab Elnashar, Todd M. Kolb, Stephen C. Mathai, Rachel L. Damico, Paul M. Hassoun, Larissa A. Shimoda, , Catherine E. Simpson
This study uses single-cell RNA sequencing to compare scleroderma-associated and idiopathic pulmonary arterial hypertension, identifying distinct pathobiological features and potential drug targets.
bioRxiv · Oct 25, 2024 · PreprintBioinformatics