Paul M. Hassoun

The paper identifies multicellular molecular programs associated with RV adaptation in PAH using single-nucleus RNA sequencing and integrates them with physiological measurements.

The paper identifies metabolic modules in PAH patients linked to RV-PV function using WGCNA and validates findings in independent cohorts.

This study shows that blocking IL-6 restores FOXP3 expression in PAH, revealing its role as a biomarker and therapeutic target.

This study identifies hResistin's role in priming and activating the NLRP3 inflammasome in macrophages, linking it to inflammatory diseases through HMGB1, BTK, and downstream cytokine production.

This study uses single-cell RNA sequencing to compare scleroderma-associated and idiopathic pulmonary arterial hypertension, identifying distinct pathobiological features and potential drug targets.

This paper classifies PAH-related genes based on evidence strength using a semi-quantitative scoring system, identifying twelve genes with definitive evidence and recommending their inclusion in genetic testing panels.