Darin T. Rosen

Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial Hypertension

The paper identifies multicellular molecular programs associated with RV adaptation in PAH using single-nucleus RNA sequencing and integrates them with physiological measurements.

Metabolomic Network Analysis Reveals Reorganization of Lipid and Steroid Programs Linked to Right Ventricular-Pulmonary Vascular Function in Pulmonary Hypertension

The paper identifies metabolic modules in PAH patients linked to RV-PV function using WGCNA and validates findings in independent cohorts.

Single-cell transcriptomics reveal diverging pathobiology and opportunities for precision targeting in scleroderma-associated versus idiopathic pulmonary arterial hypertension

This study uses single-cell RNA sequencing to compare scleroderma-associated and idiopathic pulmonary arterial hypertension, identifying distinct pathobiological features and potential drug targets.