Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis
Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman, Sridhar Selvaraj, Eric Soupène, Prathamesh Chati, Roshani Sinha, Sofia E. Luna, Carsten T. Charlesworth, Travis McCreary, Benjamin J. Lesch, Tammy Tran, Devesh Sharma, Simon N. Chu, Matthew Hebden Porteus, M. Kyle Cromer
This paper develops small molecule-inducible EPO receptors to enable erythropoiesis without recombinant EPO, reducing costs and improving scalability of RBC manufacturing.
bioRxiv · Apr 12, 2024 · PreprintSynthetic Biology