Prathamesh Chati

PepCL: A replay-based continual learning framework for updating peptide-MHC models

PepCL updates peptide-MHC predictors with new assay data while preserving prior MS knowledge, improving prediction across alleles in clinical contexts.

Uncovering differential tolerance to deletions versus substitutions with a protein language model

The paper uses a protein language model to analyze amino acid deletions in the human proteome, identifying sites with differential tolerance to deletions versus substitutions.

Engineering inducible signaling receptors to enable erythropoietin-free erythropoiesis

This paper develops small molecule-inducible EPO receptors to enable erythropoiesis without recombinant EPO, reducing costs and improving scalability of RBC manufacturing.