Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms
Sara Basse Hansen, Sergio G. Bartual, Huijie Yuan, Olawale G. Raimi, Andrii Gorelik, Andrew T. Ferenbach, Kristian Lytje, Jan Skov Pedersen, Taner Drace, Thomas P. Boesen, Daan M. F. van Aalten
This study presents multi-domain OGA structures from Trichoplax adhaerens and human, revealing allosteric regulatory mechanisms involving the pHAT domain.
Nature Communications · Oct 3, 2025Peer-reviewedMolecular Biology