Thomas P. Boesen

Structural thermodynamics by cryo-EM resolves minute energy differences in heterogeneous protein complexes.

The paper introduces a method to resolve energy differences in heterogeneous protein complexes using cryo-EM data and applies it to study cruciferin isoforms.

Structure and function of a fungal AB toxin-like chimerolectin involved in anti-nematode defense

The paper characterizes CCTX2, a fungal chimerolectin toxin, revealing its structure and mechanism of nematode toxicity through cryo-EM and functional assays.

The metallome of Methanosarcina barkeri during electron uptake from acathode

This study quantifies metal accumulation in Methanosarcina barkeri during cathodic growth and identifies metal localization, suggesting their role in extracellular electron transfer.

Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms

This study presents multi-domain OGA structures from Trichoplax adhaerens and human, revealing allosteric regulatory mechanisms involving the pHAT domain.

Extracellular vesicles from morphine-exposed prefrontal cortex carry transcriptomic and proteomic signatures of synaptic dysfunction

This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.

Small molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: Development of screening assays and insight into GluK3 structure

This study develops screening assays for modulating kainate receptors GluK1-3 and provides structural insights into GluK3's ligand-binding domain.

Structure and autoregulation of a P4-ATPase lipid flippase

The paper determines the structures of the P4-ATPase Drs2p-Cdc50p using cryo-EM, revealing autoinhibition and PI4P-dependent activation mechanisms.