Author

Tarek Safadi

University of Maryland, Baltimore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Ilia V. BaskakoviD· 5 shared Natallia MakaravaiD· 5 shared Kara Molesworth· 4 shared Narayan Prasad PanditiD· 4 shared Olga Mychko· 4 shared Olga V. BocharovaiD· 4 shared Li Zhang· 1 shared Marta M. LipinskiiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersNeuroscience

Ilia V. BaskakovORCID

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5 papers

Recent·Most cited

Targeting Astrocytic Stat3 Reveals Context-Dependent Modulation of Prion Disease

Natallia Makarava, Narayan Prasad Pandit, Olga Mychko, Kara Molesworth, Tarek Safadi, Olga V. Bocharova, Ilia V. Baskakov

This study investigates the role of astrocytic Stat3 in prion disease, finding it modulates astrocyte reactivity but has limited impact on disease progression, with context-dependent effects.

bioRxiv · Aug 20, 2026 · PreprintNeuroscience

Protective Role of Galectin-3 in Prion Disease Through Regulation of Microglial PrPSc Uptake

Natallia Makarava, Tarek Safadi, Narayan Prasad Pandit, Olga Mychko, Olga V. Bocharova, Kara Molesworth, Marta M. Lipinski, Ilia V. Baskakov

This study shows that Galectin-3 promotes microglial uptake of PrPSc, slowing prion disease progression by enhancing phagocytic sequestration of prions.

bioRxiv · Jun 16, 2026 · PreprintNeuroscience

Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

Sunitha Subhramanian, Olga V. Bocharova, Natallia Makarava, Tarek Safadi, Ilia V. Baskakov

This study identifies a novel surveillance strategy of reactive microglia in chronic neurodegeneration, showing increased somatic mobility and direct neuron engagement.

eLife · Jan 8, 2026Peer-reviewedNeuroscience

Knockout of P2Y12 receptor facilitates microglia-neuron body-to-body interactions and accelerates prion disease

Natallia Makarava, Tarek Safadi, Olga V. Bocharova, Olga Mychko, Narayan Prasad Pandit, Kara Molesworth, Ukpong B. Eyo, Ilia V. Baskakov

This study shows that P2Y12 receptor knockout increases microglia-neuron body-to-body interactions and accelerates prion disease progression in mice.

bioRxiv · Apr 7, 2025 · PreprintNeuroscience

Engulfment of viable neurons by reactive microglia in prion diseases

Natallia Makarava, Tarek Safadi, Olga Mychko, Narayan Prasad Pandit, Kara Molesworth, Simone Baiardi, Li Zhang, Piero Parchi, Ilia V. Baskakov

The paper shows that in prion diseases, microglia engulf viable neurons during late preclinical stages, independent of the CD11b pathway, and this occurs across multiple brain regions and sCJD subtypes.

bioRxiv · Mar 6, 2024 · PreprintNeuroscience