Ukpong B. Eyo

This study shows that helminth infection reduces CNS inflammation and demyelination in a mouse model of multiple sclerosis by promoting Th2 cells.

This study shows that microglia reduce seizure severity through P2RY12 signaling, as demonstrated in genetic models and seizure paradigms.

The paper identifies sex- and brain region-specific pericyte signaling changes in Alzheimer's Disease using single-nucleus RNA sequencing and spatial transcriptomics.

This study investigates how P2RY12 loss affects microglial metabolic and activation states, revealing altered metabolic pathways and increased susceptibility to ferroptosis.

This study shows that P2Y12 receptor knockout increases microglia-neuron body-to-body interactions and accelerates prion disease progression in mice.

This study shows that 7-ketocholesterol increases astrocyte oxidative stress in Alzheimer's disease via microglia activation.

This study shows microglia regulate cerebral blood flow through CD39-mediated ATP breakdown, affecting neurovascular coupling and CBF reactivity.

This study demonstrates that microglia have a beneficial role in reducing various types of seizures using a targeted approach.

This study shows spinal microglia amplify neuronal activity in inflammatory pain via the P2Y12 receptor, suggesting a therapeutic target for pain management.

The paper identifies capillary-associated microglia (CAMs) and shows they regulate vascular structure and function via PANX1-P2RY12 signaling.

This study shows that neuronal activity in awake mice influences microglial process surveillance via norepinephrine signaling, highlighting the need for awake imaging in studying microglia-neuron interactions.