Olga V. Bocharova

This study investigates the role of astrocytic Stat3 in prion disease, finding it modulates astrocyte reactivity but has limited impact on disease progression, with context-dependent effects.

This study shows that Galectin-3 promotes microglial uptake of PrPSc, slowing prion disease progression by enhancing phagocytic sequestration of prions.

This study identifies a novel surveillance strategy of reactive microglia in chronic neurodegeneration, showing increased somatic mobility and direct neuron engagement.

This study shows that P2Y12 receptor knockout increases microglia-neuron body-to-body interactions and accelerates prion disease progression in mice.

This study investigates prion strain adaptation to a new host using synthetic prions, finding that adaptation involves multiple stages including changes in PrPSc properties and microglia interaction.

This study shows that Alzheimer's disease-associated β-Amyloid does not protect against HSV-1 brain infection in 5XFAD mice.