Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol
Claude F. Albritton, Mert Demirci, Kit Neikirk, Lale A. Ertuğlu, Jeanne Ishimwe, Ashley Pitzer Mutchler, Quanhu Sheng, Cheryl L. Laffer, Celestine N. Wanjalla, Taseer Ahmed, Alexandria Porcia Haynes, Mohammad Saleem, Heather K. Beasley, Andrea Gail Marshall, Zer Vue, , Annet Kirabo
This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.
bioRxiv · Jun 10, 2024 · PreprintPhysiology