Annet Kirabo

Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Three-dimensional electron microscopy uncovers mitochondrial network remodeling in residual triple negative breast cancer persisting after conventional chemotherapy treatments.

This study uses 3D electron microscopy to analyze mitochondrial network changes in residual triple negative breast cancer after chemotherapy, revealing structural remodeling and lipid droplet interactions associated with chemoresistance.

The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer

This study investigates the association between JAK-STAT pathway gene expression and hypertension in Kenyan women with breast cancer, finding significant correlations between specific genes and blood pressure metrics.

Proteolytic Cleavage of the ENaC gamma Subunit: Impact Upon Na+ and K+ Handling

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion

This paper provides validated dietary strategies to modulate zinc homeostasis in mice and outlines methods to assess zinc status, enhancing reproducibility in disease-related studies.