Antentor Othrell Hinton Jr.

Annexin A6 modulates the secretion of pro-inflammatory cytokines and exosomes via interaction with SNAP23 in triple negative breast cancer cells

This study shows that Annexin A6 promotes secretion of pro-inflammatory cytokines and exosomes in TNBC cells through interaction with SNAP23.

Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication

This study identifies ATF4 as a master regulator of mitochondrial structural plasticity through a novel signaling axis, showing its role in stress-induced mitochondrial remodeling.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Three-dimensional electron microscopy uncovers mitochondrial network remodeling in residual triple negative breast cancer persisting after conventional chemotherapy treatments.

This study uses 3D electron microscopy to analyze mitochondrial network changes in residual triple negative breast cancer after chemotherapy, revealing structural remodeling and lipid droplet interactions associated with chemoresistance.

Senescence and DNA Damage-Induced Inflammation Drive Heart Failure with Preserved Ejection Fraction in Cardiovascular Kidney Metabolic Syndrome

This study identifies DNA damage-driven senescence and ZBP1-cGAS-STING signaling as conserved mechanisms linking cardiovascular-kidney-metabolic comorbidities to HFpEF.

The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease

This study investigates how MICOS disruption affects mitochondrial structure and function in neurons vulnerable to Alzheimer's disease, linking these changes to early mitochondrial dysfunction and neuronal vulnerability.

ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle

This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.

Derlin-mediated ERAD of lipid regulator ORMDL3 safeguards mitochondrial function

This study shows Derlin-mediated ERAD of ORMDL3 prevents mitochondrial dysfunction by maintaining sphingolipid homeostasis and ER-mitochondria contact sites.

Light Microscopy-Based Organelle Quantification: A Comprehensive Protocol

This paper provides a comprehensive protocol for quantifying cellular organelles using light microscopy and Fiji/ImageJ, enabling precise, high-throughput, and statistically comparable measurements across different samples.

Intercellular Communication via Mitotic Nanotubes is Influenced by Connexin-43 Trafficking and Actin Remodeling

This study shows that mitotic nanotubes, influenced by Cx43 trafficking and actin remodeling, enable reduced gap junction communication during cell division.

A zebrafish seizure model of cblX syndrome reveals a dose-dependent refractory response to mTor inhibition.

This study uses a zebrafish model of cblX syndrome to show that mTor inhibition at moderate doses reduces seizure severity, but higher doses cause a refractory response in hcfc1a mutants.

Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster

This study uses metabolomic profiling in Drosophila melanogaster to show that selection for early reproduction leads to repeatable metabolic changes and a reliable predictor of biological age.

Artificial intelligence-enabled automated analysis of transmission electron micrographs to evaluate chemotherapy impact on mitochondrial morphology in triple negative breast cancer

The paper introduces an AI model to analyze mitochondrial morphology in TNBC using TEM images, finding significant structural changes in response to chemotherapy and metastasis.

Changes in Myofibril Size, Shape, and Network Connectivity in Aging Muscle

This study examines changes in myofibril size, shape, and connectivity in aging muscle across mice and humans, finding increased connectivity and variable size/shape changes depending on muscle type.

Cytokine and Chemokine Receptor Profiles in Adipose Tissue Vasculature Unravel Endothelial Cell Responses in HIV

This study examines cytokine and chemokine receptor expression in adipose tissue endothelial cells of HIV-positive individuals, identifying receptor differences and their potential role in vascular dysfunction.

MIRO1 controls energy production and proliferation of vascular smooth muscle cells

This study shows MIRO1 regulates VSMC proliferation and neointima formation by controlling mitochondrial positioning, ATP production, and ETC function.

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

Myeloid Cell Glucocorticoid, Not Mineralocorticoid Receptor Signaling, Contributes to Salt-Sensitive Hypertension in Humans via Cortisol

This study identifies glucocorticoid receptor (GR) signaling in myeloid cells as a key contributor to salt-sensitive hypertension (SSBP) through SGK1 and IsoLG pathways, distinct from mineralocorticoid receptor (MR) mechanisms.

Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion

This paper provides validated dietary strategies to modulate zinc homeostasis in mice and outlines methods to assess zinc status, enhancing reproducibility in disease-related studies.