Heparan sulfate-function is essential for Integrin-dependent cell-matrix interactions and regulates glycosaminoglycan synthesis synthesis through YAP
Ann-Christine Severmann, Christoph Waterkamp, Meike Buchholz, Isabel Adorf, Lutz Fleischhauer, Julius Sefkow-Werner, Katja Jochmann, Tatjana Holzer, Velina Bachvarova, Nina Schulze, Johannes Koch, Bent Brachvogel, Elisa Migliorini, Hauke Clausen‐Schaumann, Perihan Nalbant, , Andrea Vortkamp
This study shows that heparan sulfate (HS) is critical for integrin-mediated cell-matrix interactions and regulates glycosaminoglycan (GAG) synthesis through YAP signaling in chondrocytes.
bioRxiv · Jan 8, 2026 · PreprintCell Biology