A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
Tao Li, Brian Chiou, Casey K. Gilman, Rong Luo, Tatsuhiro Koshi, Diankun Yu, Hayeon C Oak, Stefanie Giera, Erin Johnson‐Venkatesh, Allie K. Muthukumar, Beth Stevens, Hisashi Umemori, Xianhua Piao
This study identifies a specific GPR56 splicing isoform that mediates microglial synaptic pruning through phosphatidylserine binding, linking it to neurodevelopmental processes.
The EMBO Journal · May 25, 2020Peer-reviewedNeuroscience