Author

Diankun Yu

Tulane UniversityORCID 0000-0002-1390-7985Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:differential expression· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Xianhua PiaoiD· 3 shared Andi WangzhouiD· 2 shared Beika ZhuiD· 2 shared Isabella FebboiD· 2 shared Laura A. SchraderiD· 2 shared Matthieu J. MaroteauxiD· 2 shared Stacy L. De Florencio· 2 shared Tao LiiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersNeuroscience

Xianhua PiaoORCID

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6 papers

Recent·Most cited

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1

Diankun Yu, Samhita Jain, Andi Wangzhou, Beika Zhu, Wenyuan Shao, Elena J.L. Coley, Stacy L. De Florencio, Jae Yeon Kim, Jennifer Ja-Yoon Choi, Mercedes F. Paredes, Tomasz Jan Nowakowski, Eric Jinsheng Huang, Xianhua Piao

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

Nature · Aug 6, 2025Peer-reviewedNeuroscience

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease

Beika Zhu, Andi Wangzhou, Diankun Yu, Tao Li, Rachael Schmidt, Stacy L. De Florencio, Lauren Chao, Yonatan Perez, Lea T. Grinberg, Salvatore Spina, Richard M. Ransohoff, Arnold R. Kriegstein, William W. Seeley, Tomasz Jan Nowakowski, Xianhua Piao

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

bioRxiv · Oct 15, 2024 · PreprintNeuroscience

Shox2 is necessary for normal thalamic spindle function

Isabella Febbo, Matthieu J. Maroteaux, Diankun Yu, Valerie Warkins, Luis A. Martinez, Anne E. Anderson, Maria José Galazo, Laura A. Schrader

This study shows that Shox2 is essential for maintaining thalamic spindle function by regulating firing properties of thalamocortical neurons, leading to impaired sleep spindles and related behaviors.

bioRxiv · Sep 10, 2024 · PreprintNeuroscience

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

Tao Li, Brian Chiou, Casey K. Gilman, Rong Luo, Tatsuhiro Koshi, Diankun Yu, Hayeon C Oak, Stefanie Giera, Erin Johnson‐Venkatesh, Allie K. Muthukumar, Beth Stevens, Hisashi Umemori, Xianhua Piao

This study identifies a specific GPR56 splicing isoform that mediates microglial synaptic pruning through phosphatidylserine binding, linking it to neurodevelopmental processes.

The EMBO Journal · May 25, 2020Peer-reviewedNeuroscience

Astrocytes amplify neuronal dendritic volume transmission

Chun Chen, Zhiying Jiang, Xin Fu, Diankun Yu, Hai Yan Huang, Jeffrey G. Tasker

The paper reveals a novel retrograde signaling mechanism in CRF neurons where astrocytes amplify dendritic volume transmission by responding to norepinephrine-induced ATP release.

Cell Reports · Dec 1, 2019Peer-reviewedNeuroscience

The transcription factor Shox2 shapes thalamocortical neuron firing and synaptic properties

Diankun Yu, Matthieu J. Maroteaux, Yingnan Song, Xiao Han, Isabella Febbo, Claire Namboodri, Cheng Sun, Wenduo Ye, Emily Meyer, Stuart Rowe, YP Chen, LA Schrader

This study identifies Shox2 as a transcription factor regulating thalamocortical neuron firing properties and synaptic function through ion channel gene expression.

bioRxiv · Sep 6, 2019 · PreprintNeuroscience