Hisashi Umemori

The paper shows that breathing at birth triggers CO2 exhalation, which reduces mTOR activity and limits regenerative capacity in CNS neurons and other tissues, but this effect is reversible with CO2 inhalation or Snrk deletion.

This study identifies PCDH17 and PCDH10 as molecular organizers of two distinct indirect basal ganglia circuits that regulate task learning and sensorimotor habituation.

This study investigates a mouse model of PCDH19-clustering epilepsy, finding hyperthermia-induced seizures and reduced parvalbumin-expressing interneurons in specific brain regions.

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

This study identifies a specific GPR56 splicing isoform that mediates microglial synaptic pruning through phosphatidylserine binding, linking it to neurodevelopmental processes.