Author

Tatsuo Ashizawa

Houston Methodist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 1 Organism:Drosophila· 1 Approach:experimental assay· 1

Frequent Co-Authors

Albert R. La SpadaiD· 1 shared Anirban ChakrabortyiD· 1 shared Charlene Smith-GeateriD· 1 shared Chi-Lin TsaiiD· 1 shared Christopher Dirk KeeneiD· 1 shared John A. TaineriD· 1 shared Keegan M. BushiD· 1 shared Leslie Michels ThompsoniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Albert R. La SpadaORCID

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1 paper

Recent·Most cited

Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntingtons disease

Subrata Pradhan, Sagar Gaikwad, Chi-Lin Tsai, Charlene Smith-Geater, Nan Zhang, Keegan M. Bush, Anirban Chakraborty, Subo Yuan, Sanjeev Choudhary, Christopher Dirk Keene, Lisa Ellerby, Tapas K. Hazra, Albert R. La Spada, Yogesh P. Wairkar, Tatsuo Ashizawa, , Partha Sarathi Sarkar

The paper shows that Huntingtin (HTT) helps maintain mitochondrial DNA integrity by organizing a repair complex, which is disrupted by mutant HTT in Huntington's disease, leading to DNA damage and motor deficits in a fly model.

bioRxiv · Jul 24, 2025 · PreprintNeuroscience