John A. Tainer

This study reveals the dynamic catalytic mechanism of APE1 using a moving metal ion strategy, showing how Mg2+ repositioning enables efficient DNA repair without forming a pentavalent intermediate.

This study shows TDP43 regulates DNA mismatch repair genes, affecting genome stability in neurodegenerative and cancer contexts.

The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.

The paper shows that Huntingtin (HTT) helps maintain mitochondrial DNA integrity by organizing a repair complex, which is disrupted by mutant HTT in Huntington's disease, leading to DNA damage and motor deficits in a fly model.

This paper applies information theory to improve the inverse transform of small angle scattering data by defining a Shannon limit that determines resolution and model selection.

This study reveals how the BRCA2 C-terminal domain reshapes RAD51 dimers to bind B-DNA, promoting replication fork stability over homology-directed repair.

This study identifies a mechanism where HTT recruits BRG1 and NHEJ components to repair transcription-associated DSBs in neurons, and shows that mutant HTT impairs this process, contributing to HD pathology.

This study shows how DYNLL1 and Shieldin regulate DNA end resection and repair pathway choice through interactions with MRE11 and 53BP1 at DSBs.

The paper identifies structural differences in zebrafish α4 chain of type IV collagen and shows its conserved anti-angiogenic activity compared to humans.

The paper shows RNA alkylation triggers recruitment of the ASCC repair complex via RNF113A, revealing RNA damage as a signal for DNA repair.