Subo Yuan

The paper shows that Huntingtin (HTT) helps maintain mitochondrial DNA integrity by organizing a repair complex, which is disrupted by mutant HTT in Huntington's disease, leading to DNA damage and motor deficits in a fly model.

The paper develops a noninvasive imaging method to measure spontaneous pain in mice using bioluminescence from genetically modified neurons.

This study identifies a mechanism where HTT recruits BRG1 and NHEJ components to repair transcription-associated DSBs in neurons, and shows that mutant HTT impairs this process, contributing to HD pathology.

This study shows that Alzheimer's disease circulating exosomes reduce VE-cadherin expression and impair brain endothelial barrier function through RNA cargo-dependent mechanisms.

This study uses scRNA-seq to compare microglia in adult mouse brains and spinal cords, identifying subtype differences and plasticity in response to HIV-1 gp120.