Keegan M. Bush

Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntingtons disease

The paper shows that Huntingtin (HTT) helps maintain mitochondrial DNA integrity by organizing a repair complex, which is disrupted by mutant HTT in Huntington's disease, leading to DNA damage and motor deficits in a fly model.

Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons

This study identifies a mechanism where HTT recruits BRG1 and NHEJ components to repair transcription-associated DSBs in neurons, and shows that mutant HTT impairs this process, contributing to HD pathology.

Nucleoside reverse transcriptase inhibitors are the major class of HIV antiretroviral therapeutics that induce neuropathic pain in Mice

This study identifies nucleoside reverse transcriptase inhibitors (NRTIs) as the primary class of antiretrovirals causing neuropathic pain in mice, highlighting their role in peripheral sensory neuropathy.

Drosophila model of Anti-retroviral therapy Induced Peripheral Neuropathy and Nociceptive Hypersensitivity

This study develops a Drosophila model to investigate NRTI-induced peripheral neuropathy and nociceptive hypersensitivity, finding that increased neuronal dynamics contribute to these effects.