T-bet expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape
Eduard Ansaldo, Daniel Yong, Nathan Carrillo, Taryn E McFadden, Mahnoor Abid, Dan Corral, Claudia A. Rivera, Taylor K. Farley, Nicolas Jean Bouladoux, Inta Gribonika, Yasmine Belkaid
This study identifies a dominant population of IL-10-producing, T-bet-expressing CD4+ Tr1 cells in the small intestine that are shaped by dietary antigens rather than the microbiota.
Proceedings of the National Academy of Sciences · Jan 7, 2026Peer-reviewedImmunology