Eduard Ansaldo

Bone marrow B cell collapse promotes bone metastasis in breast cancer

This study shows that breast cancer cells induce B cell loss in bone marrow, promoting bone metastasis, and that G-CSF mediates this effect, suggesting B cells and G-CSF as therapeutic targets.

Alternatively activated monocyte-derived myeloid cells promote extracellular pathogen persistence within pulmonary fungal granulomas.

This study identifies alternatively activated myeloid cells as drivers of extracellular fungal persistence in pulmonary granulomas through T helper 2 cell signaling.

Microbiota-dependent IFN-L controls uterine and placental immunity.

This study identifies IFN-L as a microbiota-dependent regulator of uterine immunity, controlling both immunoregulation and antibacterial responses during pregnancy.

T-bet expressing Tr1 cells driven by dietary signals dominate the small intestinal immune landscape

This study identifies a dominant population of IL-10-producing, T-bet-expressing CD4+ Tr1 cells in the small intestine that are shaped by dietary antigens rather than the microbiota.

PI3Kdelta promotes T cell effector differentiation and plasticity during chronic infection

This study shows that activated PI3Kdelta reduces TCF-1+ stem-like CD8+ T cells but promotes effector differentiation and viral control during chronic infection.

Antibiotic use in early life subsequently impairs MAIT cell-mediated immunity

This study shows that early-life antibiotic use reduces MAIT cell abundance, impairing immunity to pneumonia, but this effect can be reversed by reintroducing riboflavin-synthesizing commensals.

Endogenous retroelements promote tolerance to dietary antigens

This study shows that endogenous retroelements promote tolerance to dietary antigens by regulating regulatory T cell function and dendritic cell activity through innate sensing pathways.

Spatial organization of pulmonary type 2 inflammation by a macrophage-derived cholesterol metabolite

The paper identifies a cholesterol metabolite that spatially organizes TH2 cells during fungal-induced pulmonary inflammation, promoting fungal persistence and suppressing interferon-gamma responses.