Human TSC2 Mutant Cells Exhibit Aberrations in Early Neurodevelopment Accompanied by Changes in the DNA Methylome
Mary‐Bronwen L. Chalkley, Lindsey N. Guerin, Tenhir Iyer, Samantha Mallahan, Sydney Nelson, Mustafa Şahin, Emily C. Hodges, Kevin C. Ess, Rebecca A. Ihrie
This study shows that TSC2 mutant cells exhibit early neurodevelopmental abnormalities and DNA methylation changes, suggesting early gene regulation disruption in TSC.
Human Molecular Genetics · Jan 22, 2025Peer-reviewedDevelopmental Biology