Emily C. Hodges

The paper identifies mutation-specific impairments in TET2 and DNMT3A enzymatic activity as predictors of clonal hematopoiesis disease risk using methylation-based activity scores.

The paper identifies islet-specific DNA hypomethylated regions linked to T2D risk by integrating DNA methylation data with GWAS and EHR data.

The paper shows that chromatin accessibility and DNA demethylation occur at different times during enhancer regulation, with methylation states predicting chromatin dynamics using machine learning.

This study shows that TSC2 mutant cells exhibit early neurodevelopmental abnormalities and DNA methylation changes, suggesting early gene regulation disruption in TSC.

The paper identifies cis and trans regulatory element divergence between humans and rhesus macaques using ATAC-STARR-seq, finding that most divergent elements show changes in both mechanisms.

The paper identifies mutation-specific targets for PIK3CA hotspot mutations using a multi-modal genomics approach and isogenic cell lines.

The paper identifies DNA hypomethylated regions (HMRs) across human cell types and developmental stages, showing their role in gene regulation and trait heritability.

This study identifies genes associated with both depression and coronary artery disease that are enriched for inflammation and cardiomyopathy pathways, and finds higher prevalence of cardiomyopathy in individuals with comorbid depression-CAD.

The paper uses ATAC-STARR-seq to analyze regulatory activity, chromatin accessibility, and TF occupancy in human lymphoblastoid cells, finding 30% of accessible regions contain activators, silencers, or both.