Multi-Objective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance
Martin Toul, Veronika Slonková, Jan Mičan, Sandra Thalerová, Michaela Pešková, Patrícia Kittová, Peter Scheer, Jana Hložková, Eliška Brhelová, Ahmet Davut AKSU, Jan Biskupič, Michaela Kuchynka, Jaroslav Ondruš, Petr Kašpárek, Tereza Batkova, , Zbyněk Prokop
This paper designs next-generation thrombolytic proteases with improved catalytic efficiency, fibrin selectivity, and inhibition resistance through multi-objective enzyme engineering.
ACS Catalysis · Sep 22, 2026Peer-reviewedBiochemistry