Author

Sandra Thalerová

Czech Academy of Sciences, Institute of BiophysicsORCID 0000-0002-7257-8317Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ahmet Davut AKSUiD· 1 shared David BednářiD· 1 shared Eliška BrhelováiD· 1 shared Jan BiskupičiD· 1 shared Jan MičaniD· 1 shared Jan VítečekiD· 1 shared Jana HložkováiD· 1 shared Jaroslav OndrušiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Ahmet Davut AKSUORCID

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1 paper

Recent·Most cited

Multi-Objective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance

Martin Toul, Veronika Slonková, Jan Mičan, Sandra Thalerová, Michaela Pešková, Patrícia Kittová, Peter Scheer, Jana Hložková, Eliška Brhelová, Ahmet Davut AKSU, Jan Biskupič, Michaela Kuchynka, Jaroslav Ondruš, Petr Kašpárek, Tereza Batkova, , Zbyněk Prokop

This paper designs next-generation thrombolytic proteases with improved catalytic efficiency, fibrin selectivity, and inhibition resistance through multi-objective enzyme engineering.

ACS Catalysis · Sep 22, 2026Peer-reviewedBiochemistry