The fate of secretory cells during intestinal homeostasis, regeneration, and tumor formation is regulated by Tcf4
Lucie Janečková, Monika Šťastná, Dušan Hrčkulák, Linda Berková, Jan Kubovčiak, Jakub Onhajzer, Vı́tězslav Křı́ž, Stela Dostalikova, Tereza Mullerova, Kateřina Večerková, Marketa Tenglerova, Štěpán Coufal, Klara Kostovcikova, Richard S. Blumberg, Dominik Filipp, , Vladimír Kořínek
This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.
bioRxiv · Jul 11, 2024Molecular Biology