Jan Kubovčiak

This study shows Wnt signaling regulates NG2 glia fate in adult mouse cortex, promoting neuronal conversion while impairing oligodendrocyte maturation after ischemic injury.

This study shows that the PRPF8-Y2334N variant causes photoreceptor defects in human neural retina cells without affecting the retinal pigment epithelium.

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

The paper identifies an astrocyte-like NG2 glia subpopulation in adult mouse cortex that shows neurogenic potential and can form neuron-like cells after ischemic injury.

This study shows that mutations in Prpf8 in mice lead to misexpression of circRNAs and cerebellar granule neuron degeneration.