Author

Vı́tězslav Křı́ž

Czech Academy of SciencesORCID 0009-0002-9151-9889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dušan HrčkulákiD· 2 shared Jakub OnhajzeriD· 2 shared Lucie JanečkováiD· 2 shared Monika Šťastná· 2 shared Vladimír KořínekiD· 2 shared Dominik FilippiD· 1 shared Jan KubovčiakiD· 1 shared Kateřina VečerkováiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Dušan HrčkulákORCID

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2 papers

Recent·Most cited

Development of a new flippase-dependent mouse model for red fluorescence-based isolation of KrasG12D oncogene-expressing tumor cells

Dušan Hrčkulák, Jakub Onhajzer, Michaela Krausová, Monika Šťastná, Vı́tězslav Křı́ž, Lucie Janečková, Vladimír Kořínek

This paper develops a flippase-dependent mouse model that expresses KrasG12D and red fluorescent protein, enabling selective isolation and analysis of tumor cells.

Transgenic Research · Jan 9, 2025Peer-reviewedCancer Biology

The fate of secretory cells during intestinal homeostasis, regeneration, and tumor formation is regulated by Tcf4

Lucie Janečková, Monika Šťastná, Dušan Hrčkulák, Linda Berková, Jan Kubovčiak, Jakub Onhajzer, Vı́tězslav Křı́ž, Stela Dostalikova, Tereza Mullerova, Kateřina Večerková, Marketa Tenglerova, Štěpán Coufal, Klara Kostovcikova, Richard S. Blumberg, Dominik Filipp, , Vladimír Kořínek

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

bioRxiv · Jul 11, 2024Molecular Biology