Konrad Basler

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

This study shows that innate immune pathway activation can promote tumor growth when combined with oncogenic Ras in Drosophila.

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

The paper introduces a CRISPR/Cas9-based mouse model for lineage tracing and gene manipulation in Lgr5+ intestinal stem cells without affecting endogenous Lgr5 function.

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.

This study shows that the Toll pathway inhibits tissue growth and enhances cell fitness in an infection-dependent manner by regulating apoptosis and proliferation.

The paper introduces a multicolor BiFC library for studying protein-protein interactions in live Drosophila using Hox proteins as a case study.

The paper identifies a biphasic mode of sarcomere development in Drosophila flight muscles, regulated by Spalt major, with distinct phases of assembly and maturation.