Dominik Filipp

This paper describes a method to co-isolate AAV with extracellular vesicles for efficient genome editing in rodent embryos, achieving higher viability and targeting efficiency compared to traditional purification methods.

The study identifies Claudin 1 on DC1s as essential for their positioning near mTECs, facilitating antigen transfer and DC1 maturation, which maintains central tolerance.

The paper shows that HSCs and Tregs work together to maintain extramedullary hematopoiesis during chronic inflammation.

This study investigates the role of Tcf4 in intestinal epithelial regeneration and tumorigenesis using mouse models and RNA sequencing, finding that Tcf4 loss shifts cell lineage from Paneth to goblet cells and affects tumor cell phenotypes.

This study identifies Lyl-1 as a critical regulator of primitive macrophage and microglia development, showing its role in progenitor emergence and differentiation.