Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
Geetika Aggarwal, Subhashis Banerjee, Spencer A. Jones, Yousri Benchaar, Jasmine Bélanger, Myriam Sévigny, Denise M. Smith, Michael L. Niehoff, Monica Pavlack, Ian Mitchelle S. de Vera, Terri L. Petkau, Blair R. Leavitt, Karen Ling, Paymaan Jafar‐Nejad, Frank Rigo, , Andrew D. Nguyen
This study shows that antisense oligonucleotides can increase progranulin protein levels by blocking miR-29b binding in GRN mRNA, offering a potential therapy for FTD.
Journal of Biological Chemistry · Nov 17, 2023Peer-reviewedNeuroscience