A tracheal aspirate-derived airway basal cell model reveals a pro-inflammatory epithelial defect in congenital diaphragmatic hernia
Richard Wagner, Gaurang M. Amonkar, Wei Wang, Jessica E. Shui, Kamakshi Bankoti, Wai Hei Tse, Frances A. High, Jill M. Zalieckas, Terry L. Buchmiller, Augusto Zani, Richard Keijzer, Patricia K. Donahoe, Paul H. Lerou, Xingbin Ai
This study develops a human airway basal cell model from tracheal aspirates to investigate epithelial defects in congenital diaphragmatic hernia, finding a pro-inflammatory signature and therapeutic response to steroids.
American Journal of Respiratory and Critical Care Medicine · Feb 2, 2023Peer-reviewedDevelopmental Biology