Author

Paul H. Lerou

Massachusetts General HospitalORCID 0000-0002-6777-7389Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Xingbin AiiD· 3 shared Rachel FearnsiD· 2 shared Yan Bai· 2 shared Alice Emma TalientoiD· 1 shared Augusto ZaniiD· 1 shared Caiqi ZhaoiD· 1 shared Caiqi Zhao· 1 shared Daisy W. LeungiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Xingbin AiORCID

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Author profile →

3 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedJul 21, 2026

An immune-poised state of human bronchial epithelial cells mediates RSV resistance in adults

Caiqi Zhao, Yan Bai, Hongmei Mou…·Xingbin Ai

The paper identifies an age-associated immune-poised state in human bronchial epithelial cells that mediates RSV resistance in adults by enhancing RIG-I-STAT3 signaling.

DOI 10.1038/s41467-026-75842-8

humanbulk RNA-seq

Cell BiologyAmerican Journal of Respiratory and Critical Care MedicinePeer-reviewedFeb 18, 2026

Infant RSV infection desensitizes β2-adrenergic receptor via CXCL11-CXCR7 signaling in airway smooth muscle

Caiqi Zhao, Alice Emma Taliento, Elise M. Belkin…·Yan Bai

This study shows RSV infection desensitizes β2AR in infant ASMCs via CXCL11-CXCR7 signaling, leading to airway resistance and potential therapeutic targeting.

2 citationstop 3%

humanmouse

Developmental BiologyAmerican Journal of Respiratory and Critical Care MedicinePeer-reviewedFeb 2, 2023

A tracheal aspirate-derived airway basal cell model reveals a pro-inflammatory epithelial defect in congenital diaphragmatic hernia

Richard Wagner, Gaurang M. Amonkar, Wei Wang…·Xingbin Ai

This study develops a human airway basal cell model from tracheal aspirates to investigate epithelial defects in congenital diaphragmatic hernia, finding a pro-inflammatory signature and therapeutic response to steroids.

31 citationstop 2%

humanrat