Augusto Zani

This study shows that amniotic fluid stem cell extracellular vesicles improve lung development in a fetal rat model of oligohydramnios by modulating TGF-beta signaling through miR-93-5p.

The paper identifies miRNAs selectively loaded into extracellular vesicles from healthy human astrocytes and links them to neurodevelopmental disorders.

This study shows mechanical compression disrupts fetal lung vascular development in CDH, but amniotic fluid stem cell extracellular vesicles reverse these effects via Hippo signaling pathway modulation.

This study identifies hypoxic injury and loss of neural cells in fetal brains with congenital diaphragmatic hernia using a rat model and human autopsy samples.

This study develops a human airway basal cell model from tracheal aspirates to investigate epithelial defects in congenital diaphragmatic hernia, finding a pro-inflammatory signature and therapeutic response to steroids.

Amniotic fluid stem cell extracellular vesicles improve fetal lung development in CDH by modulating macrophage inflammation and restoring normal gene expression.

The paper shows that amniotic fluid stem cell extracellular vesicles restore autophagy in hypoplastic lungs, improving branching morphogenesis in rodent and human models.

This study shows that amniotic fluid stem cell extracellular vesicles rescue lung development in a rat model of congenital diaphragmatic hernia by restoring branching morphogenesis and cell differentiation.

The paper demonstrates that extracellular vesicles from amniotic fluid stem cells can rescue impaired fetal lung development in experimental models.