Alzheimer's Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain Development
Yiqiao Wang, Johan Lorentz, Elyas Mohammadi, Dilsah Ezgi Yilmaz, Theologos Sgouras, Yuxi Guo, Giusy Pizzirusso, Aphrodite Demetriou, Ivan Nalvarte, Marianne Schultzberg, Xiaofei Li
This study shows AD mutations impair neural stem cell fate and early brain development, leading to structural vulnerabilities that may increase AD risk later in life.
bioRxiv · Mar 16, 2025 · PreprintDevelopmental Biology