Elyas Mohammadi

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

Alzheimer's Disease Mutations Disrupt Neural Stem Cell Fate and Early Brain Development

This study shows AD mutations impair neural stem cell fate and early brain development, leading to structural vulnerabilities that may increase AD risk later in life.

Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics

The paper introduces DeepCellMap, a deep learning tool for analyzing spatial cellular organization in developing brains, revealing microglial phenotypes and spatial clustering patterns.

Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology

This study profiles cell-type specific changes in human entorhinal cortex at early Alzheimer's disease stages, identifying dysregulation of Reelin signaling and downregulation of NPTX2 and CBLN4.

Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

The paper investigates LOY in TME leukocytes, finding higher LOY frequency in Tregs and its association with immune checkpoint receptor expression.

Drug repositioning for immunotherapy in breast cancer using single-cell and spatial transcriptomics analysis

This study identifies immunomodulatory peptides deregulated in breast cancer using single-cell and spatial transcriptomics, and proposes drugs to modulate their expression.

Size matters - the impact of nucleus size on results from spatial transcriptomics

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.

Design and Computational Analysis of a Chimeric Avian Influenza Antigen: A Yeast-displayed, Universal and Cross-protective Vaccine Candidate

The paper designs and computationally analyzes two chimeric avian influenza antigens, finding that the second design better interacts with a monoclonal antibody and could serve as a vaccine candidate.