Purine nucleobases enhance CD8+ T cell effector function
Jakob‐Wendelin Genger, Ben Haladik, Alexander Lercher, Benedikt Agerer, Carolina Mangana, Fabian Amman, Csilla Viczenczová, Theresa Hohl, Anna Hofmann, Maximilian Koblischke, Bernhard Kratzer, Wentao Li, Kerstin Zinober, Felix Kartnig, Christina Schüller, , Andreas Bergthaler
This study identifies purine nucleobases as immunometabolites that enhance CD8+ T cell effector function by enabling a metabolic switch from de novo synthesis to salvage pathway.
bioRxiv · Aug 14, 2025 · PreprintImmunology